Celebrating 50 Years of Cancer Research: Milestones and Innovations at MIT

Throughout 2024, a significant milestone has been marked in the field of cancer research as we celebrate 50 years of groundbreaking advancements. A new exhibition titled ‘Object Lessons: Celebrating 50 Years of Cancer Research at MIT in 10 Items’ was inaugurated on November 19, inviting the public to explore pivotal artifacts that highlight MIT’s influential journey in the battle against cancer.

Exhibition Overview

This exhibition showcases key artifacts, such as one of the earliest PCR machines from Nobel laureate H. Robert Horvitz’s lab and Greta, an innovative zebra fish from Professor Nancy Hopkins’s research. Together, these items represent the significant discoveries that have placed MIT at the forefront of cancer research.

Since the establishment of the Center for Cancer Research in 1974, MIT has been a leader in cancer biology. The National Cancer Act of 1971 ignited a commitment to better understand and combat cancer, leading to the creation of a center where leading biologists could address fundamental questions about the disease.

Innovation and Impact

The Koch Institute, founded in 2011, has fostered a collaborative environment that integrates engineers and life scientists, facilitating transformative progress against cancer. Over the past 13 years, this interdisciplinary approach has led to significant advances in understanding cancer biology and translating those findings into impactful patient outcomes.

The research conducted at the Koch Institute has birthed over 120 spin-out companies, many based in the nearby Kendall Square area. Almost half of these companies have successfully moved their technologies into clinical trials or commercial applications, demonstrating a tangible impact on healthcare.

Personal Stories and Artifacts

Matthew Vander Heiden, Current Director of Koch Institute, says: “Our lab work is essential in changing the reality of cancer for patients. We remain motivated by the urgent need to translate our research into improved outcomes for those affected by cancer.”

One notable exhibit is Salvador Luria’s ceramic mug, featuring ‘Luria’s broth’, which symbolizes the early foundation of cancer research at MIT and Luria’s visionary influence. This artifact is a testament to the pioneering spirit that has shaped MIT’s cancer research legacy.

The BioBits imaging device, developed by Jessica Stark, exemplifies modern advancements in biological education and accessibility. As Jessica explains, “BioBits kits aim to provide equitable STEM education, inspiring the next generation of scientists.”

Alex Shalek’s messenger bag and Seq-Well device reflect his dedication to advancing single-cell sequencing technology globally. He states, “Collaborative partnerships are at the heart of transformative cancer research.”

“Our lab work is essential in changing the reality of cancer for patients. We remain motivated by the urgent need to translate our research into improved outcomes for those affected by cancer.” – Matthew Vander Heiden

Human Impact

A poignant exhibit includes a 3D-printed model of Steven Keating’s brain tumor, a powerful reminder of the human stories behind scientific advancements. Keating became an advocate for patient rights and contributed to significant developments in therapies for IDH-mutant glioma, culminating in FDA approval for vorasidenib in 2024.

Looking Ahead

“As we look forward, our collaborative environment positions us to continue uncovering critical insights in cancer research. The passion and innovation that have driven us for 50 years will guide us into the future.”

Object Lessons is open to the public in the Koch Institute Public Galleries from Monday to Friday, 9 a.m. to 5 p.m., through spring semester 2025.